Human Sera
Cayman Chemical GInkgotoxIn 50mg
A xanthine derivative and neuroprotective agent increases NGF production in primary mouse astroglia maximally at 1.11 mM reduces AB42-induced cell death in primary rat hippocampal neurons at 20 Ug/ml reduces infarct volume in a rat model of ischemic brain damage induced by permanent MCAO when administered following MCAO as an i.v. infusion at 0.01 0.05 and 0.1 mg/kg per minute inhibits cAMP phosphodiesterases is an antagonist of adenosine A1 and A2 receptors and binds to adenosine transporters
Cayman Chemical 7Methoxy4 trIfluoromethyl 50mg
An anthelmintic and anticancer agent dietary administration reduces worm burden in mouse models of N. dubius S. obvelata or A. tetraptera infection (EC50s 292 4 and 17 ppm respectively) lethal to mice at higher concentrations (LC50 600 ppm in the diet) induces cytotoxicity in PANC-1 cells cultured in glucose-deficient medium but not serum- or amino acid-deficient medium or complete medium at 1 g/ml reduces tumor growth in a PANC-1 mouse xenograft model at 100 g/mouse per day binds to and activates CK1a at 10 nM inhibits Wnt signaling (EC50 ~10 nM in a reporter assay) in a CK1a-dependent manner
Cayman Chemical CephalosporIn CzInc 100mg
An internal standard for the quantification of etofenamate by GC- or LC-MS
Cayman Chemical HArgGlyAspCysOHtrIfluo 100mg
An active metabolite of bradykinin and a peptide agonist of the bradykinin B1 receptor binds to bradykinin B1 and B2 receptors (IC50 8.1 UM in CHO cells expressing the human receptor) induces relaxation of precontracted isolated endothelium-denuded dog renal artery strips (pD2 8.6) decreases blood pressure in LPS-treated rabbits in a dose-dependent manner
Cayman Chemical NIfenalolhydrochlorIde 50mg
A Smac mimetic and IAP inhibitor binds to the BIR3 domains of IAP1 IAP2 and XIAP (IC50s 15 21 and 15 nM respectively) disrupts the protein-protein interaction between IAP1 and caspase-9 in vitro induces degradation of IAP1 in (EC50 0.1 nM) and reduces the growth of MDA-MB-231 breast cancer cells (GI50 T cell spleen thymus bone marrow liver lung and lymph node levels of HIV RNA in a humanized mouse model of antiretroviral therapy-suppressed HIV infection at 3 mg/kg
Cayman Chemical GadoterIdol 50mg
A triterpene scavenges DPPH radicals in a cell-free assay at 0.8 mM prevents arsenic-induced decreases in the activity of SOD1 catalase GST and glutathione reductase in mouse brain at 20 mg/kg for four days reduces tumor growth in an Ehrlich murine spontaneous adenocarcinoma model at 100 and 250 mg/kg for 20 days reduces cisplatin-induced renal fibrosis and increased kidney TNF-a and IL-1B levels in mice at 100 and 250 mg/kg per day for 10 days
Cayman Chemical CytIdIn 3-monphosphate 50mg
A P2X7 receptor antagonist inhibits BzATP-evoked intracellular calcium influx in 1321N1 cells expressing human rat and mouse receptors (IC50s 20 42 and 150 nM respectively) inhibits BzATP-induced YO-PRO dye uptake and IL-1B release from THP-1 cells (IC50s 6.6 and 37 nM respectively) reduces thermal hyperalgesia in rats at 30 100 and 300 Umol/kg i.p. reduces thermal and mechanical hyperalgesia in a rat MRMT-1 mammary carcinoma model of cancer-induced bone pain at 40 mg/kg
Cayman Chemical Perhydrofarnsyl Aceton 50mg
A Smac mimetic and IAP inhibitor binds to the BIR3 domains of IAP1 IAP2 and XIAP (IC50s 15 21 and 15 nM respectively) disrupts the protein-protein interaction between IAP1 and caspase-9 in vitro induces degradation of IAP1 in (EC50 0.1 nM) and reduces the growth of MDA-MB-231 breast cancer cells (GI50 T cell spleen thymus bone marrow liver lung and lymph node levels of HIV RNA in a humanized mouse model of antiretroviral therapy-suppressed HIV infection at 3 mg/kg
Cayman Chemical GlutamInase-IN-3 100mg
A chymase inhibitor (IC50s 4 and 3 nM for the human and hamster enzyme respectively) reduces isoprenaline-induced cardiac fibrosis in hamsters at 1 3 and 10 mg/kg inhibits decreases in left ventricular ejection fraction and increases in left ventricular end-systolic volume decreases in plasma levels of nt-proBNP TGF-B1 and TNF-a as well as the levels of interstitial fibrosis and the cross-sectional area of myocytes in a coronary microembolism-induced canine model of heart failure at 2 and 5 mg/kg per day
Cayman Chemical Esomeprazole 50mg
A steroid selectively inhibits OATP1B1 over OATP1B3 (IC50s 0.06 and 19.3 UM respectively)
Cayman Chemical SulfaethoxypyrIdazIn 50mg
An Hsp90 inhibitor binds to the C-terminal domain of Hsp90a and inhibits the protein-protein interaction between the Hsp90a C-terminal domain and PPID decreases cell viability and induces apoptosis in HER2-positive BT474 and SK-BR-3 cells at 0.5-20 UM reduces mammosphere formation by as well as Hsf-1 Hsp70 and Hsp90 protein levels in BT474 cells at 10 UM reduces intratumoral levels of HER2 and ICD-HER2 as well as reduces tumor growth and angiogenesis in a trastuzumab-resistant JIMT-1 mouse xenograft model at 30 mg/kg
Cayman Chemical PTI-125hydrochlorIde 50mg
An inhibitor of the Hsp70-BAG-3 protein-protein interaction (IC50 1.6 UM) reduces the proliferation of MDA-MB-231 and MCF-7 cells (EC50s 0.4 and 0.7 UM respectively) and 22 other cancer cell lines (EC50s 0.3-4 UM) toxic to MEFs (EC50 22 UM) reduces tumor growth in MCF-7 breast cancer and HeLa cervical cancer mouse xenograft models at 3 mg/kg every two days
Cayman Chemical AmbenonIumchlorIde 50mg
A synthetic bioactive sphingolipid active against C. glabrata and C. albicans (MFC 0.5 Ug/ml for both) has commonly been used as an internal standard for the detection of sphingolipids in chromatographic and mass spectrometry applications
Cayman Chemical ACTAmInophen GlucuronIdSo 50mg
An esterified form of pentadecanoic acid has been found as a minor component in biodiesels made from the transesterification of beef tallow soybean oil and babassu oil blends has been found in latent fingerprint residue samples