Human Sera
Cayman Chemical GastrodIa elta Gastrodn 100mg
A phenolic glycoside with diverse biological activities; reduces Aβ42-induced cell death of rat hippocampal neurons and BV-2 mouse microglia; improves learning and memory in various transgenic mouse models of Alzheimer's disease; reduces motor deficits and loss of dopaminergic neurons in a rat model of Parkinson's disease; reduces seizure duration and intensity in a rat model of pentylenetetrazole-kindling chronic epileptic seizures from 50-200 mg/kg; increases social interaction and decreases marble burying and grooming behaviors, as well as restores inhibitory synaptic transmission and GAT1 and α5 subunit-containing GABAA expression in the basolateral amygdala in a mouse model of valproic acid-induced autistic-like phenotypes at 100 mg/kg; increases biomechanical bone strength in a rat model of dexamethasone-induced osteoporosis; inhibits ethanol-induced hepatocellular apoptosis and restores liver function in a rat model of alcoholic liver disease
Sigma Aldrich Fine Chemicals Biosciences BOVINE SERUM ALBUM LYOPHILIZED
NC3038695 BOVINE SERUM ALBUM LYOPHILIZED
Cayman Chemical -CnabIchromen 50mg
An analytical reference standard categorized as a phytocannabinoid; induces catalepsy, hypothermia, hypolocomotion, and antinociception in the mouse tetrad assay for cannabimimetic activity; intended for research and forensic applications
Cayman Chemical Lersvrn 50mg
An NNRTI (mean IC50 = 118 nM for the wild-type HIV-1 enzyme); inhibits mutant HIV-1 RTs with mean IC50 values within 10-fold of the wild-type enzyme; inhibits HIV-1 virus replication in MT-2 cells (EC50s = 5.04, 13.1, and 34.9 nM at MOIs of 0.005, 0.05, and 0.5, respectively); exhibits synergistic or additive effects when used in combination with a variety of antiretroviral agents
Cayman Chemical N-MethylcytIsIn 100mg
An alkaloid with diverse biological activities; an nAChR agonist; selectively binds to nAChRs over mAChRs (IC50s = 0.05 and 417 µM, respectively); elicits whole-cell currents in Xenopus oocytes expressing α4β2, α4β4, and α7 subunit-containing nAChRs (EC50s = 13, 13, and 340 µM, respectively); nematocidal against B. xylophilus; inhibits LPS-induced NO production in RAW 264.7 macrophages (IC50 = 33.3 µM) and proliferation of SMMC-7721 cells at 4 mg/ml
Cayman Chemical AmorolfInhydrochlorIde 100mg
An antifungal; active against isolates of T. rubrum, T. mentagrophytes, and C. albicans (MIC90s = 4-15, 4-60, and ≤30-500 ng/ml, respectively); inhibits the growth of T. mentagrophytes and T. rubrum by 33.7 and 38.5%, respectively, in an in vitro bovine hoof model of onychomycosis; decreases the fungal burden in a rabbit model of onychomycosis when used as a 5% nail lacquer
Cayman Chemical RaltItrexed 100mg
An inhibitor of thymidylate synthase (Ki = 62 nM); inhibits the growth of L1210 mouse lymphocytic leukemia cells in vitro (IC50 = 8 nM); reduces thymidylate synthase activity and completely eliminates tumors in a mouse L1210:ICR ascitic tumor model at 4 mg/kg; reduces tumor growth and the number of metastases in an HCT116-luc mouse xenograft model
Cayman Chemical EpInastInhydrochlorIde 100mg
A histamine H1 receptor antagonist (apparent Kis = 1.41 and 1.62 nM using guinea pig cerebellar and lung membranes, respectively) and mast cell stabilizer; inhibits IgE-induced histamine, TNF-α, and IL-10 secretion in human CBMCs at 0.1 μg/ml; inhibits histamine-induced cutaneous vascular permeability in rats and bronchoconstriction in anesthetized guinea pigs (ID50s = 5 and 0.1 mg/kg, respectively); inhibits dye leakage into the conjunctiva in a rat model of passive anaphylaxis reaction-induced vascular hyperpermeability of the conjunctiva (ID50 = 9.7 mg/kg, p.o.); topical administration reduces lid edema, tearing, and redness, as well as the number of neutrophils and eosinophils in the lid fornix, in a mouse model of atopic conjunctivitis
Cayman Chemical 1S 3S3Hydroxycyclopentn 50mg
A synthetic intermediate useful for pharmaceutical synthesis.
Cayman Chemical DaunorubIcInon 50mg
An aglcyone form of the antitumor antibiotic daunorubicin; has been used as a starting material in the synthesis of anticancer agents
Cayman Chemical Fluorometholon 50mg
A synthetic glucocorticoid that binds to glucocorticoid receptors (IC50 = 1.5 nM; Kd = 2.8 nM); decreases survival of cultured corneal epithelial cells and inhibits their migration in a scratch assay following 12 hours of treatment (0.01%)
Cayman Chemical PImonIdazole 100mg
A small molecule radiosensitizer that has proven to be an effective and nontoxic immunochemical hypoxia marker for human squamous cell carcinomas of the cervix, head and neck
Cayman Chemical SpermIn Nonate 100mg
Spermine NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 39 minutes and 230 minutes at 37°C and 22-25°C, respectively, (pH 7.4) to liberate 2 moles of NO per mole of parent compound.{875,5437}
Cayman Chemical 7 pMethoxybenzylamIno4nI 100mg
A fluorescent probe for hydrophobic regions of proteins; upon binding to a hydrophobic region of a protein, displays an emission of 530 nm upon excitation at 430 nm
Cayman Chemical Valeroyl SalIcylate 50mg
Valeroyl salicylate is a selective, irreversible inhibitor of COX-1. The IC50 values for ovine COX-1 and -2 are 0.8 mM and 15 mM, respectively.{1364} The half-lives for inactivation of human recombinant and ovine COX-1 in the presence of 500 µM valeroyl salicylate are 12 and 45 minutes, respectively.{1284,1364}